Dennis E Vance Selected Research

Phosphatidylethanolamine N-Methyltransferase

1/2019	Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.
1/2017	Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase.
1/2016	Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice.
9/2015	Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT.
4/2015	Vagus nerve contributes to the development of steatohepatitis and obesity in phosphatidylethanolamine N-methyltransferase deficient mice.
2/2015	Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice.
1/2013	Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.
4/2011	The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis.
7/2010	Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.
9/2009	Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice.

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Dennis E Vance Research Topics

Disease

16	Obesity 10/2020 - 06/2005
12	Fatty Liver 01/2019 - 05/2006
10	Insulin Resistance 10/2021 - 07/2006
8	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 11/2002
7	Atherosclerosis 10/2017 - 12/2007
7	Liver Failure 03/2013 - 03/2004
6	Non-alcoholic Fatty Liver Disease 10/2019 - 04/2012
5	Inflammation (Inflammations) 01/2019 - 04/2012
5	Muscular Dystrophies (Muscular Dystrophy) 08/2010 - 02/2006
4	Fibrosis (Cirrhosis) 01/2019 - 01/2016
4	Type 2 Diabetes Mellitus (MODY) 01/2013 - 06/2005
3	Body Weight (Weight, Body) 01/2016 - 09/2007
2	Weight Gain 02/2016 - 07/2010
2	Alcoholic Fatty Liver 02/2015 - 12/2011
2	Metabolic Diseases (Metabolic Disease) 02/2013 - 06/2010
2	Hyperglycemia 01/2013 - 06/2005
2	Neoplasms (Cancer) 08/2010 - 01/2003
2	Alzheimer Disease (Alzheimer's Disease) 10/2009 - 02/2007
2	Ganglion Cysts (Ganglion) 10/2009 - 06/2005
2	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2007 - 03/2006
1	Overnutrition 10/2019
1	Cholestasis 02/2019
1	Liver Diseases (Liver Disease) 01/2017
1	Coronary Disease (Coronary Heart Disease) 01/2016
1	Hypothermia 09/2015
1	Hypoglycemia (Reactive Hypoglycemia) 09/2015
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/2014
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 07/2014
1	Choline Deficiency 01/2012
1	Intrahepatic Cholestasis 04/2011
1	Breast Neoplasms (Breast Cancer) 10/2010
1	Congenital Abnormalities (Deformity) 08/2010

Drug/Important Bio-Agent (IBA)

15	Phosphatidylethanolamine N-MethyltransferaseIBA 01/2019 - 01/2003
13	Phosphatidylcholines (Phosphatidylcholine)IBA 02/2019 - 03/2004
13	Choline (Choline Chloride)IBA 02/2019 - 03/2004
7	Phospholipids (Phosphatides)FDA LinkGeneric 10/2019 - 02/2006
6	Lipoproteins (Lipoprotein)IBA 10/2017 - 02/2007
6	Pharmaceutical PreparationsIBA 02/2013 - 06/2005
5	Triglycerides (Triacylglycerol)IBA 01/2019 - 09/2003
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 03/2006
5	Fatty Acids (Saturated Fatty Acids)IBA 01/2017 - 12/2007
4	EnzymesIBA 10/2020 - 02/2006
4	phosphatidylethanolamineIBA 01/2019 - 05/2006
4	LipidsIBA 01/2017 - 12/2007
4	CholesterolIBA 01/2016 - 05/2005
4	Choline KinaseIBA 04/2010 - 02/2006
3	Glucose (Dextrose)FDA LinkGeneric 10/2021 - 01/2012
3	Insulin (Novolin)FDA Link 01/2019 - 01/2012
2	Bile Acids and Salts (Bile Acids)IBA 02/2019 - 09/2007
2	MethyltransferasesIBA 01/2019 - 06/2008
2	Adenosine Triphosphate (ATP)IBA 01/2019 - 08/2014
2	VLDL LipoproteinsIBA 09/2017 - 09/2003
2	Messenger RNA (mRNA)IBA 01/2016 - 01/2003
2	S-Adenosylmethionine (Ademetionine)IBA 10/2013 - 01/2007
2	ApolipoproteinsIBA 03/2013 - 12/2007
2	Apolipoprotein E4IBA 10/2009 - 02/2007
2	Retinaldehyde (Retinal)IBA 10/2009 - 06/2005
2	Apolipoproteins B (ApoB)IBA 12/2007 - 08/2007
2	Apolipoprotein B-100 (Apo B 100)IBA 08/2007 - 09/2003
2	ThiazolidinedionesIBA 07/2006 - 06/2005
2	Rosiglitazone (Avandia)FDA Link 07/2006 - 06/2005
2	Complementary DNA (cDNA)IBA 09/2003 - 11/2002
1	Antisense OligonucleotidesIBA 10/2021
1	CeramidesIBA 01/2019
1	DiglyceridesIBA 01/2019
1	GangliosidesIBA 01/2019
1	AntioxidantsIBA 01/2019
1	Membrane LipidsIBA 01/2019
1	Adenosine Triphosphatases (ATPase)IBA 01/2019
1	Vitamin E FDA LinkGeneric 01/2019
1	very low density lipoprotein triglycerideIBA 01/2017
1	Fenofibrate (CiL)FDA LinkGeneric 01/2017
1	Ezetimibe (Zetia)FDA Link 01/2017
1	Pioglitazone (Actos)FDA Link 01/2016
1	Matrix Metalloproteinases (MMPs)IBA 01/2016
1	Tissue Inhibitor of MetalloproteinasesIBA 01/2016
1	CollagenIBA 01/2016
1	Alanine Transaminase (SGPT)IBA 01/2016
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2016
1	Capsaicin (Zostrix)FDA Link 04/2015
1	Azacitidine (5 Azacytidine)FDA Link 07/2014
1	DNA (Deoxyribonucleic Acid)IBA 07/2014
1	AntimetabolitesIBA 07/2014
1	LDL Receptors (LDL Receptor)IBA 03/2013
1	Glucagon (Glukagon)FDA Link 01/2013
1	Glucagon Receptors (Glucagon Receptor)IBA 01/2013
1	SodiumIBA 04/2011
1	Apolipoproteins E (ApoE)IBA 03/2011
1	Hormones (Hormone)IBA 10/2010
1	Tamoxifen FDA LinkGeneric 10/2010
1	Estrogens (Estrogen)FDA Link 10/2010
1	Phosphorylcholine (Phosphocholine)IBA 08/2010
1	Betaine (C.B.B.)FDA Link 07/2010
1	Protein Isoforms (Isoforms)IBA 04/2010
1	Insulin-Like PeptidesIBA 05/2009
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 05/2009

Therapy/Procedure

3	Therapeutics 02/2019 - 07/2006
1	Induced Hypothermia 09/2015
1	Hepatectomy 04/2012
1	Transplantation 04/2012